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Alveolar epithelial cell senescence predominates over macrophage senescence in driving pulmonary fibrosis

2026-08-27

Abstract excerpt

<title>Abstract</title> <p> Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease in which cellular senescence contributes to disease pathogenesis. However, the relative contributions of senescent macrophages and alveolar epithelial cells (AECs) to fibrosis progression remain unclear. Here, we investigated the cell type-specific roles of senescence in pulmonary fibrosis using p16 <sup>INK4...

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Literature Corpus work
db078e0c-a15c-5731-a559-1c82be2dfdf6
DOI
10.21203/rs.3.rs-10671953/v1
Open publication

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Alveolar epithelial cell senescence predominates over macrophage senescence in driving pulmonary fibrosisDOI 10.21203/rs.3.rs-10671953/v1
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