Article

Impaired SOX17 Expression Causes Endothelial Dysfunction and Pulmonary Arterial Hypertension by Insufficient Suppression of RUNX1

2026-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies have identified rare and common mutations associated with increased risk of pulmonary arterial hypertension (PAH), but the mechanism by which impaired SOX17 expression increases PAH risk is not known. Notably, SOX17 plays a critical role in endothelial identity during development by suppressing RUNX1 through binding to its promoter and directing stem and progenito...

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Literature Corpus work: 8056e827-4d84-5a1a-b53d-bf5343352de8
DOI: 10.64898/2026.05.14.725187

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