Article
The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence.
Nature communications - 24 Apr 2015
Montes Marta, Nielsen Morten M, Maglieri Giulia, Jacobsen Anders, Højfeldt Jonas, Agrawal-Singh Shuchi, Hansen Klaus, Helin Kristian, van de Werken Harmen J G, Pedersen Jakob S, Lund Anders H
Abstract excerpt
Oncogene-induced senescence (OIS) can occur in response to oncogenic insults and is considered an important tumour suppressor mechanism. Here we identify the lncRNA MIR31HG as upregulated in OIS and find that knockdown of MIR31HG promotes a strong p16(INK4A)-dependent senescence phenotype. Under normal conditions, MIR31HG is found in both nucleus and cytoplasm, but following B-RAF expression MIR31HG is located...
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