Article

P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: role of the A2A/CD39/CD73 axis

2024-11-04

Abstract excerpt

<title>Abstract</title> <p>Extracellular vesicle-driven cancer metastasis represents a therapeutic challenge due to the lack of effective blocking drugs. This study reveals a unique mechanism involving the P2X7 receptor and the A2A/CD39/CD73 axis, which affects ATP and adenosine levels in cancer via vesicular release, thereby enhancing metastasis. It also introduces a novel P2X7-based therapeutic approach to targ...

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Literature Corpus work: 04fb7b8a-a6b2-59c9-b770-41ad1543bea3
DOI: 10.21203/rs.3.rs-5287461/v1

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