Article
Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells.
BMC cancer - 1 Aug 2015
Mulvey Hillary E, Chang Audrey, Adler Jason, Del Tatto Michael, Perez Kimberly, Quesenberry Peter J, Chatterjee Devasis
Abstract excerpt
BACKGROUND: Extracellular vesicles (EVs) are secreted from many cells, carrying cargoes including proteins and nucleic acids. Research has shown that EVs play a role in a variety of biological processes including immunity, bone formation and recently they have been implicated in promotion of a metastatic phenotype. METHODS: EVs were isolated from HCT116 colon cancer cells, 1459 non-malignant colon fibroblast...
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