Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor

Abstract excerpt

ABSTRACT P2X7 is the largest member of the P2X subfamily of purinergic receptors. A typical feature is the carboxyl tail, which allows formation of a large pore. Recently a naturally occurring truncated P2X7 splice variant, isoform B (P2X7B), has been identified. Here we show that P2X7B expression in HEK293 cells, a cell type lacking endogenous P2X receptors, mediated ATP‐stimulated channel activity but not...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adenosine and Purinergic Signaling
• Share to Adolescent and Pediatric Healthcare
• Share to Bipolar Disorder and Treatment