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Article

Intravenous injection of tumor extracellular vesicles suppresses tumor growth by reducing the regulatory T cell phenotype.

Cancer immunology, immunotherapy : CII - 1 Nov 2023

Kobayashi Sanshiro, Kondo Naoyuki, Tomiyama Takashi, Nakamura Naohiro, Masuda Masataka, Matsumoto Yasushi, Honzawa Yusuke, Tahara Tomomitsu, Ikeura Tsukasa, Fukui Toshiro, Okazaki Kazuichi, Naganuma Makoto

Abstract excerpt

BACKGROUND: Colorectal cancer is a disease of unmet medical need. Although extracellular vesicles (EVs) have been implicated in anti-tumor responses, discrepancies were observed among studies. We analyzed the role of tumor-derived EVs (TEVs) in tumor progression in vivo by focusing on regulatory T (Treg) cells, which play essential roles in tumor development and progression. METHODS: A mouse model of colorectal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37597014
DOI: 10.1007/s00262-023-03517-0
PMCID: PMC10991856

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