Article
Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients.
Acta neuropathologica communications - 17 Feb 2021
Kenkhuis Boyd, Somarakis Antonios, de Haan Lorraine, Dzyubachyk Oleh, IJsselsteijn Marieke E, de Miranda Noel F C C, Lelieveldt Boudewijn P F, Dijkstra Jouke, van Roon-Mom Willeke M C, Höllt Thomas, van der Weerd Louise
Abstract excerpt
Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as increased iron levels. Therefore, using histological methods, multispectral immunofluorescence and an automated...
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