Article

Iron-loading is a prominent feature of activated microglia in Alzheimer’s disease patients

2021-01-27

Abstract excerpt

Brain iron accumulation has been found to accelerate disease progression in Amyloid β-positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key-players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as increased iron levels. Therefore, using histological methods, multispectral immunofluorescence and an automated in-house dev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eae32020-d93e-51a6-aefa-76f24aaedd94
DOI: 10.1101/2021.01.27.428379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Iron-loading is a prominent feature of activated microglia in Alzheimer’s disease patientsDOI 10.1101/2021.01.27.428379Read

Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients.Semantic proximity Read

Dystrophic microglia are a disease associated microglia morphology in the human brainSemantic proximity Read

Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer’s diseaseSemantic proximity Read

Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's diseaseSemantic proximity Read

Microglia in Alzheimer’s DiseaseSemantic proximity Read

An image segmentation pipeline optimized for human microglia uncovers sources of morphological diversity in Alzheimer’s diseaseSemantic proximity Read

Beyond Activation: Characterizing Microglial Functional Phenotypes.Semantic proximity Read

Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus.Semantic proximity Read

Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.Semantic proximity Read

All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer’s diseaseSemantic proximity Read

An overview on microglial origin, distribution, and phenotype in Alzheimer's disease.Semantic proximity Read

Knockdown of microglial iron import gene, DMT1, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer’s diseaseSemantic proximity Read