Article

Amyloid-β-regulated gene circuits for programmable Alzheimer’s disease therapy

2025-03-17

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disease characterized in part by the accumulation of the protein amyloid-β (Aβ). Monoclonal antibodies (mAbs) that target Aβ for clearance from the brain have received FDA approval; however, these therapies are accompanied by serious side effects, and their cognitive benefit for patients remains of tremendous debate. Here, we present a potential engineered cell thera...

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Literature Corpus work: fb29f32b-13b7-556e-9a97-eefc33c7939d
DOI: 10.1101/2025.03.12.642808

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