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Article

Bone-Marrow-Derived Microglia-Like Cells Ameliorate Brain Amyloid Pathology and Cognitive Impairment in a Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Kawanishi Shohei, Takata Kazuyuki, Itezono Shouma, Nagayama Hiroko, Konoya Sayaka, Chisaki Yugo, Toda Yuki, Nakata Susumu, Yano Yoshitaka, Kitamura Yoshihisa, Ashihara Eishi

Abstract excerpt

Microglia, the primary immune cells in the brain, sense pathogens and tissue damage, stimulate cytokine production, and phagocytosis to maintain homeostasis. Accumulation of amyloid-β peptides (Aβ) in the brain triggers the onset of Alzheimer's disease (AD). Accordingly, promotion of Aβ clearance represents a promising strategy for AD therapy. We previously demonstrated that primary-cultured rat microglia...

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PMID: 29914020
DOI: 10.3233/JAD-170994

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