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Article

Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities

2021-10-20

Abstract excerpt

Long noncoding RNAs (lncRNAs) are widely dysregulated in cancer, yet their functional roles in cellular disease hallmarks remain unclear. Here we employ pooled CRISPR deletion to perturb all 831 lncRNAs in KRAS-mutant non-small cell lung cancer (NSCLC), and measure their contribution to proliferation, chemoresistance and migration across two cell backgrounds. Integrative analysis of this data outperforms conventio...

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Identifiers and source

Literature Corpus work
04ecb3e1-82b9-50f0-9f62-71ccf2edd14b
DOI
10.1101/2021.10.19.464956
Open publication

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Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilitiesDOI 10.1101/2021.10.19.464956
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