Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.

doi:10.1016/j.ccell.2015.09.006

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Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.

Cancer cell - 12 Oct 2015

Yan Xiaohui, Hu Zhongyi, Feng Yi, Hu Xiaowen, Yuan Jiao, Zhao Sihai D, Zhang Youyou, Yang Lu, Shan Weiwei, He Qun, Fan Lingling, Kandalaft Lana E, Tanyi Janos L, Li Chunsheng, Yuan Chao-Xing, Zhang Dongmei, Yuan Huiqing, Hua Keqin, Lu Yiling, Katsaros Dionyssios, Huang Qihong, Montone Kathleen, Fan Yi, Coukos George, Boyd Jeff, Sood Anil K, Rebbeck Timothy, Mills Gordon B, Dang Chi V, Zhang Lin

Abstract excerpt

The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with...

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PMID: 26461095
DOI: 10.1016/j.ccell.2015.09.006
PMCID: PMC4777353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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