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Article

Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington’s disease

2025-03-16

Abstract excerpt

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG-repeat expansion in exon-1 of the huntingtin gene. Currently, no disease-modifying therapies are available, with a significant challenge in evaluating therapeutic efficacy before clinical symptoms emerge. This highlights the need for early biomarkers and intervention strategies. Therefore, it is essential to develop and characte...

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Literature Corpus work
04ca7638-c74b-54df-b0e8-65886742898b
DOI
10.1101/2025.03.16.643551
Open publication

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Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington’s diseaseDOI 10.1101/2025.03.16.643551
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