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Article

Temporal Phenotypic Changes in Huntington's Disease Models for Preclinical Studies.

Journal of Huntington's disease - 1 Jan 2022

St-Cyr Sophie, Smith Alicia R, Davidson Beverly L

Abstract excerpt

BACKGROUND: Mouse models bearing genetic disease mutations are instrumental in the development of therapies for genetic disorders. Huntington's disease (HD) is a late-onset lethal dominant genetic disorder due to a CAG repeat within exon 1 of the Huntingtin (Htt) gene. Several mice were developed to model HD through the expression of a transgenic fragment (exon 1 of the human HTT), the knock-in mutation of the...

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Identifiers

PMID: 35213386
DOI: 10.3233/JHD-210515
PMCID: PMC9028736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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