Article

Longitudinal Preclinical Evaluation of the Novel Radioligand [11C]CHDI-626 for PET Imaging of Mutant Huntingtin Aggregates in Huntington’s Disease

2021-09-02

Abstract excerpt

<title>Abstract</title> PurposeAs several therapies aimed at lowering mutant huntingtin (mHTT) brain levels in Huntington’s disease (HD) are currently being investigated, noninvasive positron emission tomography (PET) imaging of mHTT could be utilized to directly evaluate therapeutic efficacy and monitor disease progression. Here we characterized and longitudinally assessed the novel radioligand [11...

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Literature Corpus work: 8c0c7bac-6667-54e1-ac24-61e194c5dc5f
DOI: 10.21203/rs.3.rs-845228/v1

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