Article

Mapping and reprogramming human tissue microenvironments with MintFlow

2025-06-26

Abstract excerpt

Tissue microenvironments reprogram local cellular states in disease, yet current computational spatial methods remain descriptive and do not simulate tissue perturbation. We present MintFlow, a generative AI algorithm that learns how the tissue microenvironment influences cell states and predicts how tissue perturbations can reprogram them. Applied to three human diseases, MintFlow uncovered distinct pathogenic sp...

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Literature Corpus work: 4ada12f8-b9b1-511d-a4a8-ec0da7581bf1
DOI: 10.1101/2025.06.24.661094

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