Article

Deep generative selection models of T and B cell receptor repertoires with soNNia

2020-11-05

Abstract excerpt

Subclasses of lymphocytes carry different functional roles to work together and produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens. The lymphocyte subclasses emerge from common ancestors generated with the same diversity of receptors during selection processes. Here we leve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 423fdcc5-95df-5d7c-a5db-553a95110997
DOI: 10.1101/2020.11.05.370346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep generative selection models of T and B cell receptor repertoires with soNNiaDOI 10.1101/2020.11.05.370346Read

Deep generative selection models of T and B cell receptor repertoires with soNNiaSemantic proximity Read

What Do Generative Models Learn About Adaptive Immune Receptor Repertoires? A Benchmark StudySemantic proximity Read

Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution.Semantic proximity Read

Learning Human T Cell Behaviors through Generative AI Embeddings of T Cell ReceptorsSemantic proximity Read

OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifsSemantic proximity Read

Quantifying lymphocyte receptor diversitySemantic proximity Read

T-cell receptor specificity landscape revealed through de novo peptide designSemantic proximity Read

OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifsSemantic proximity Read

Reading the repertoire: Progress in adaptive immune receptor analysis using machine learningSemantic proximity Read

AI-Enabled Generative Design of Immune Cells and Receptors for Programmable ImmunitySemantic proximity Read

Simulation of adaptive immune receptors and repertoires with complex immune information to guide the development and benchmarking of AIRR machine learningSemantic proximity Read

Genesis of the αβ T-cell receptorSemantic proximity Read