Article

N-acetyl-l-leucine lowers pS129-synuclein and improves synaptic function in models of Parkinson’s disease

2025-04-09

Abstract excerpt

<title>Abstract</title> <p>N-acetyl-L-leucine (NALL), a derivative of the branched-chain amino acid leucine, has shown therapeutic potential in neurodegenerative diseases, including in prodromal stages of Parkinson’s disease (PD). However, the mechanism of its protective effects has been largely unknown. Using discovery-based proteomics, we found that treatment with NALL led to upregulation of lysosomal, mitochon...

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Literature Corpus work: 04adbe2e-476a-5e73-b3ef-daa6d2f61643
DOI: 10.21203/rs.3.rs-6298077/v1

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