Article

Depopulation of α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

2018-12-19

Abstract excerpt

<h4>SUMMARY</h4> Parkinson’s Disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood. We generated a new transgenic mouse line (MI2) expressing human, aggregation-prone truncated 1-120 α-synuclein under the control of the tyrosin...

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Literature Corpus work: 4a935761-53e3-571a-81ae-57c1dffe07d5
DOI: 10.1101/500629

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