Article

Dietary Amino Acids Impact LRRK2-induced Neurodegeneration in Parkinson’s Disease Models

2020-01-16

Abstract excerpt

<h4>ABSTRACT</h4> The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of Parkinson’s disease (PD) and results in age-related dopamine neuron loss and locomotor dysfunction in Drosophila melanogaster through an aberrant increase in bulk neuronal protein synthesis. Under non-pathologic conditions, protein synthesis is tightly controlled by metabolic regulation. Whether nutritional and met...

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Literature Corpus work: 600b0915-7a26-5f94-ab9e-0992fce37770
DOI: 10.1101/2020.01.13.905471

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