Article

High molecular weight insoluble parkin in the substantia nigra of patients with idiopathic Parkinson’s disease

2025-12-02

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is characterized by a loss of dopaminergic neurons and accumulation of α-synuclein (α-syn)-containing Lewy bodies in the substantia nigra (SN) pars compacta. Mutations in the gene coding for the protein parkin cause a form of autosomal recessive juvenile parkinsonism, but its role in idiopathic PD is poorly understood. Here, to investigate parkin changes in the...

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Literature Corpus work: 2d1b8fbc-6fc4-578a-bcb4-069d95c850e3
DOI: 10.21203/rs.3.rs-8098616/v1

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