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Article

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2.

Biochemical Society transactions - 1 Oct 2012

Tong Youren, Shen Jie

Abstract excerpt

Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common genetic cause of PD (Parkinson's disease). To investigate how mutations in LRRK2 cause PD, we generated LRRK2 mutant mice either lacking its expression or expressing the R1441C mutant form. Homozygous R1441C knockin mice exhibit no dopaminergic neurodegeneration or alterations in steady-state levels of striatal dopamine, but they show impaired...

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Identifiers

PMID: 22988862
DOI: 10.1042/BST20120112
PMCID: PMC9112632

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Source receipt: pubmed, retrieved 7 Sept 2026.

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