Article
Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging
2020-03-19
Abstract excerpt
<title>Abstract</title> <p>Background: The APOE Ɛ4 genotype is the most prevalent genetic risk for Alzheimer's disease (AD). Women carriers of Ɛ4 have higher risk for an early onset of AD than men. Human imaging studies suggest apolipoprotein E4 may affect brain structures associated with cognitive decline in AD many years before disease onset. It was hypothesized that female APOE Ɛ4 carriers would present with d...
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Identifiers and source
- Literature Corpus work
- 049fc07a-72b5-5912-95d9-1cd08a2ac8b4
- DOI
- 10.21203/rs.3.rs-18040/v1