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Article

Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging.

Brain research - 15 Nov 2020

Kulkarni Praveen, Grant Simone, Morrison Thomas R, Cai Xuezhu, Iriah Sade, Kristal Bruce S, Honeycutt Jennifer, Brenhouse Heather, Hartner Jochen C, Madularu Dan, Ferris Craig F

Abstract excerpt

The APOE Ɛ4 genotype is the most prevalent genetic risk for Alzheimer's disease (AD). Women carriers of Ɛ4 have higher risk for an early onset of AD than men. Human imaging studies suggest apolipoprotein Ɛ4 may affect brain structures associated with cognitive decline in AD many years before disease onset. It was hypothesized that female APOE Ɛ4 carriers would present with decreased cognitive function and...

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PMID: 32745658
DOI: 10.1016/j.brainres.2020.147030

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