Article
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998
Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas R E, Mahley R W, Mucke L
Abstract excerpt
Apolipoprotein E (apoE) mediates the redistribution of lipids among cells and is expressed at highest levels in brain and liver. Human apoE exists in three major isoforms encoded by distinct alleles (epsilon2, epsilon3, and epsilon4). Compared with APOE epsilon2 and epsilon3, APOE epsilon4 increa...
Topics
- Age Factors
- Alleles
- Animals
- Apolipoproteins E
- Avoidance Learning
- Exploratory Behavior
- Female
- Humans
- Immunohistochemistry
- Maze Learning
- Mice
- Mice, Knockout
- Mice, Transgenic
- Neurons
- Phosphopyruvate Hydratase