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Article

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998

Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas R E, Mahley R W, Mucke L

Abstract excerpt

Apolipoprotein E (apoE) mediates the redistribution of lipids among cells and is expressed at highest levels in brain and liver. Human apoE exists in three major isoforms encoded by distinct alleles (epsilon2, epsilon3, and epsilon4). Compared with APOE epsilon2 and epsilon3, APOE epsilon4 increases the risk of cognitive impairments, lowers the age of onset of Alzheimer's disease (AD), and decreases the response...

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Source

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Identifiers

PMID: 9724804
DOI: 10.1073/pnas.95.18.10914
PMCID: PMC27995

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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