Article

Modulation of metabolic, inflammatory, fibrotic and cell death pathways by Resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): A transcriptomic profiling study

2025-11-30

Abstract excerpt

Metabolic dysfunction–associated steatohepatitis (MASH) is a growing global burden with limited therapeutic options, and the mechanisms driving disease regression remain incompletely understood. Resmetirom, a selective thyroid hormone receptor-β (THR-β) agonist, has been approved for MASH, yet its molecular actions require further clarification. In this study, we employed a diet-induced mouse model of MASH using f...

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Literature Corpus work: 7fa8f64b-869c-56af-ba4c-817e44631405
DOI: 10.1101/2025.11.26.690715

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