Article

Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia

2021-11-07

Abstract excerpt

Wnt signalling is an evolutionary conserved signal transduction pathway heavily implicated in normal development and disease. The central mediator of this pathway, β-catenin, is frequently overexpressed, mislocalised and overactive in acute myeloid leukaemia (AML) where it mediates the establishment, maintenance and drug resistance of leukaemia stem cells. Critical to the stability, localisation and activity of β-...

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Literature Corpus work: 04743cba-601f-5eec-a9e1-b3ba66bae7f9
DOI: 10.1101/2021.11.06.467095

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