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Article

The role of the Wilms tumour gene (<i>WT1</i>) in normal and malignant haematopoiesis

1 May 2007

Abstract excerpt

In addition to its loss playing a pivotal role in the development of a childhood kidney malignancy, the Wilms tumour 1 gene (WT1) has emerged as an important factor in normal and malignant haematopoiesis. Preferentially expressed in CD34+ haematopoietic progenitors and down-regulated in more-differentiated cells, the WT1 transcription factor has been implicated in regulation of apoptosis, proliferation and...

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PMID: 17524167
DOI: 10.1017/s1462399407000336

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