Article

Dual targeting a LIN28B:β-catenin axis in acute myeloid leukaemia

2026-01-27

Abstract excerpt

<h4>Background</h4> Wnt/β-catenin signalling is dysregulated in acute myeloid leukaemia (AML), where it lacks effective targeting strategies. Previously, we discovered that β-catenin interacts with several RNA-binding proteins (RBP), indicating post-transcriptional influence which is yet to be therapeutically interrogated in AML. <h4>Methods</h4> Co-immunoprecipitation confirmed protein interactions, and TCF/LEF...

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Literature Corpus work: 032e020d-81c4-592d-938c-6fb6bff3f2dd
DOI: 10.64898/2026.01.25.698240

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