Article
WNT/beta-catenin pathway activation in Wilms tumors: a unifying mechanism with multiple entries?
Genes, chromosomes & cancer - 1 Sept 2009
Corbin Marie, de Reyniès Aurélien, Rickman David S, Berrebi Dominique, Boccon-Gibod Liliane, Cohen-Gogo Sarah, Fabre Monique, Jaubert Francis, Faussillon Marine, Yilmaz Funda, Sarnacki Sabine, Landman-Parker Judith, Patte Catherine, Schleiermacher Gudrun, Antignac Corinne, Jeanpierre Cécile
Abstract excerpt
Based on characterization of both genomic and expression status of WT1 and CTNNB1 (beta-catenin) in a series of 60 Wilms tumor samples, combined with genome-wide expression profiling of these tumors, normal mature and fetal kidney controls, we show that WT1/beta-catenin expression was a better classifier than WT1/CTNNB1 mutations. We present molecular data supporting that the WNT pathway is involved in both tumor...
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