Article
Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia.
Blood - 4 Jun 2009
Hollink Iris H I M, van den Heuvel-Eibrink Marry M, Zimmermann Martin, Balgobind Brian V, Arentsen-Peters Susan T C J M, Alders Marielle, Willasch Andre, Kaspers Gertjan J L, Trka Jan, Baruchel Andre, de Graaf Siebold S N, Creutzig Ursula, Pieters Rob, Reinhardt Dirk, Zwaan C Michel
Abstract excerpt
Wilms tumor 1 (WT1) mutations have recently been identified in approximately 10% of adult acute myeloid leukemia (AML) with normal cytogenetics (CN-AML) and are associated with poor outcome. Using array-based comparative genome hybridization in pediatric CN-AML samples, we detected a WT1 deletion in one sample. The other WT1 allele was mutated. This prompted us to further investigate the role of WT1 aberrations...
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