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Article

Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy

12 Dec 2024

Abstract excerpt

• WT1 exhibits diverse roles and mechanisms of action across various malignancies. • Multiple therapeutic approaches target WT1, including synthetic drugs, natural products, and vaccines. • WT1-targeted immunotherapy is advancing through clinical trials, bringing it closer to potential clinical application in the near future. Wilms tumor 1 (WT1) is a multifaceted protein with dual functions, acting both as a...

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PMID: 39672002
DOI: 10.1016/j.tranon.2024.102237

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