Article
CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors.
The American journal of pathology - 1 Dec 2004
Li Chi-Ming, Kim Connie E, Margolin Adam A, Guo Meirong, Zhu Jimmy, Mason Jacqueline M, Hensle Terrence W, Murty Vundavalli V V S, Grundy Paul E, Fearon Eric R, D'Agati Vivette, Licht Jonathan D, Tycko Benjamin
Abstract excerpt
Gain-of-function mutations in exon 3 of beta-catenin (CTNNB1) are specific for Wilms' tumors that have lost WT1, but 50% of WT1-mutant cases lack such "hot spot" mutations. To ask whether stabilization of beta-catenin might be essential after WT1 loss, and to identify downstream target genes, we compared expression profiles in WT1-mutant versus WT1 wild-type Wilms' tumors. Supervised and nonsupervised...
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