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Article

Exercise mitigates high-fat diet-induced cardiac dysfunction via APOE genotype- and immune-dependent mechanisms: A photon-counting CT study in adult mice.

PloS one - 1 Jan 2025

Nadkarni Rohan, Allphin Alex J, Clark Darin P, Qi Yi, Han Zay Yar, Ghaghada Ketan B, Badea Alexandra, Badea Cristian T

Abstract excerpt

BACKGROUND: Cardiovascular dysfunction frequently accompanies aging and is often worsened by adverse lifestyle factors and genetic susceptibility. The apolipoprotein E (APOE) gene modulates susceptibility to cardiovascular disease, but how exercise and diet interact with APOE genotype remains insufficiently understood. We investigate the cardioprotective potential of exercise in humanized APOE-targeted...

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Topics

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Share to Apolipoproteins E
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Transgenic

Share to Physical Conditioning, Animal

Share to Tomography, X-Ray Computed

Source

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Identifiers

PMID: 41417779
DOI: 10.1371/journal.pone.0339293
PMCID: PMC12716737

Genes

APOE
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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