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An <em>In Silico</em> Study of a Novel rpoB Insertion in a Cluster of Clinical Strains of <em>Mycobacterium tuberculosis</em> Highly-Rifampicin Resistant

2017-07-27

Abstract excerpt

Rifampicin is one of the most important chemotherapeutic agents used in the treatment of tuberculosis. M. tuberculosis clinical strains resistant to rifampicin harbor mainly mutation in an 81-base pair region of rpoB. These mutations mainly consist of single amino acid substitutions. However insertions also can be related with rifampicin resistance strains. Herein, we described an insertion of 12 nucleotides in cl...

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Literature Corpus work
044fcaff-da7c-5c4f-9b8e-f5e1c935ae53
DOI
10.20944/preprints201707.0078.v1
Open publication

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