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A highly rifampicin resistant Mycobacterium tuberculosis strain emerging in Southern Brazil.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2020

Rossetti Maria Lucia, Almeida da Silva Pedro Eduardo, Salvato Richard Steiner, Reis Ana Júlia, Schiefelbein Sun Hee, von Groll Andrea, Barcellos Regina Bones, Maschmann Raquel, Esteves Leonardo Souza, Spies Fernanda, Trespach Rubia Raubach, Dalla Costa Elis Regina, Neubauer de Amorim Hermes Luís

Abstract excerpt

Here we described phenotypical, molecular and epidemiological features of a highly rifampicin-resistant Mycobacterium tuberculosis strain emerging in Southern Brazil, that carries an uncommon insertion of 12 nucleotides at the codon 435 in the rpoB gene. Employing a whole-genome sequencing-based study on drug-resistant Mycobacterium tuberculosis strains, we identified this emergent strain in 16 (9.19%) from 174...

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PMID: 33137698
DOI: 10.1016/j.tube.2020.102015

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