Article

Intracellular Drug Targets In Mycobacterium Tuberculosis Revealed By A Chemo-Genetic Approach

2021-12-28

Abstract excerpt

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. It causes chronic lung diseases to one third of the world’s population. Chemo-genetic characterization through in vitro evolution combined with whole genome sequencing analysis can identify novel drug targets and drug resistance genes in Mtb. We performed a genome analysis of 53 M...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0641f4e0-91b4-5335-a9f3-84910bc5c250
DOI: 10.21203/rs.3.rs-946186/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intracellular Drug Targets In Mycobacterium Tuberculosis Revealed By A Chemo-Genetic ApproachDOI 10.21203/rs.3.rs-946186/v1Read

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.Semantic proximity Read

Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.Semantic proximity Read

Alterations in molecular response of Mycobacterium tuberculosis against anti-tuberculosis drugs.Semantic proximity Read

Drug resistance mechanisms and drug susceptibility testing for tuberculosis.Semantic proximity Read

Decoding drug resistance in Mycobacterium tuberculosis complex: genetic insights and future challenges.Semantic proximity Read

Drug resistance mechanisms and novel drug targets for tuberculosis therapySemantic proximity Read

Genome analyses of 174 strains of Mycobacterium tuberculosis provide insight into the evolution of drug resistance and reveal potential drug targets.Semantic proximity Read

Multidrug-resistant tuberculosis: a comprehensive review of pathogenesis, drug resistance, current treatment and future prospects.Semantic proximity Read

Drug-Resistant Tuberculosis: A Glance at Progress and Global Challenges.Semantic proximity Read

The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 drugs in China from a nationwide survey: a genomic analysis.Semantic proximity Read

Target Identification in Anti-Tuberculosis Drug DiscoverySemantic proximity Read

Rapid determination of anti-tuberculosis drug resistance from whole-genome sequencesSemantic proximity Read