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Predicting rifampicin resistance in <i>M. tuberculosis</i> using machine learning informed by protein structural and chemical features

2024-08-15

Abstract excerpt

<h4>Background</h4> Rifampicin remains a key antibiotic in the treatment of tuberculosis. Despite advances in cataloguing resistance-associated variants (RAVs), novel and rare mutations in the relevent gene, rpoB , will be encountered in clinical samples, complicating the task of using genetics to predict whether a sample is resistant or not to rifampicin. We have trained a series of machine learning models with...

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Literature Corpus work
b278c217-f321-5766-8a58-5a2f8fdd3074
DOI
10.1101/2024.08.15.608097
Open publication

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Predicting rifampicin resistance in <i>M. tuberculosis</i> using machine learning informed by protein structural and chemical featuresDOI 10.1101/2024.08.15.608097
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