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rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis

1 Oct 2021

Abstract excerpt

Objective: To investigate the mutations within the whole rpoB gene of Mycobacterium tuberculosis and analyze their effects on rifampin (RIF) resistance based on crystal structure. Methods: We sequenced the entire rpoB gene in 175 tuberculosis isolates and quantified their minimum inhibitory concentrations using microplate-based assays. Additionally, the structural interactions between wild-type/mutant RpoB and...

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PMID: 34675557
DOI: 10.2147/idr.s333433

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