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Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.

Molecules (Basel, Switzerland) - 12 Jul 2022

Tsui Clement K M, Sorrentino Flavia, Narula Gagandeep, Mendoza-Losana Alfonso, Del Rio Ruben Gonzalez, Herrán Esther Pérez, Lopez Abraham, Bojang Adama, Zheng Xingji, Remuiñán-Blanco Modesto Jesus, Av-Gay Yossef

Abstract excerpt

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. Chemical-genetic characterization through in vitro evolution combined with whole genome sequencing analysis was used identify novel drug targets and drug resistance genes in Mtb associated with its intracellular growth in human macrophages. We performed a genome analysis of 53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35889319
DOI: 10.3390/molecules27144446
PMCID: PMC9324642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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