Article

Simplified and Rapid Workflow Enhances Throughput of <i>De Novo</i> Sequencing of COVID-19 Neutralizing Antibodies

2024-08-12

Abstract excerpt

<h4>ABSTRACT</h4> During the current COVID-19 pandemic, precise antibody sequencing is crucial for the rapid development of broad-spectrum or pan-β-coronavirus neutralizing antibodies (NAbs) to prevent new variants of the coronavirus and other highly pathogenic β-coronaviruses. However, mass spectrometry-based de novo sequencing remains challenging due to its high cost, low throughput, and unexpected missing of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 042db850-6ead-5077-bc54-f8106ae9d495
DOI: 10.1101/2024.08.09.607349

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Simplified and Rapid Workflow Enhances Throughput of <i>De Novo</i> Sequencing of COVID-19 Neutralizing AntibodiesDOI 10.1101/2024.08.09.607349Read

<i>de Novo</i> Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 VaccinationSemantic proximity Read

AbNovoBench: a resource and benchmarking platform for monoclonal antibody de novo sequencingSemantic proximity Read

<i>In silico</i> approach toward the identification of unique peptides from viral protein infection: Application to COVID-19Semantic proximity Read

Template-based assembly of proteomic short reads for <i>de novo</i> antibody sequencing and repertoire profilingSemantic proximity Read

Ultrafast Microdroplet Digestion of Antibodies with Fc-Silencing Mutations.Semantic proximity Read

Next-generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody RepertoireSemantic proximity Read

Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingSemantic proximity Read

The Challenges and Breakthroughs in the Development of Diagnostic Monoclonal AntibodiesSemantic proximity Read

Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical DiscoverySemantic proximity Read

The proteomic toolbox for identification, quantification, and characterization of polyclonal antibodiesSemantic proximity Read

Atomically accurate de novo design of antibodies with RFdiffusionSemantic proximity Read

Data-driven evaluation of suitable immunogens for improved antibody selectionSemantic proximity Read