Article

<i>de Novo</i> Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 Vaccination

2024-03-15

Abstract excerpt

We present a method for sequencing polyclonal IgG enriched from human plasma, employing a combination of de novo sequencing, proteomics, bioinformatics, protein separation, sequencing, and peptide separations. Our study analyzes a single patient’s IgG antibody response triggered by the Moderna Spikevax mRNA COVID-19 vaccine. From the sequencing data of the natural polyclonal response to vaccination, we generated...

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Literature Corpus work: b183d369-4494-53f8-bb6d-c530bcf93cda
DOI: 10.1101/2024.03.14.583523

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