Article

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling

2023-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Wnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here we report for the first time that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a methyl sterol oxidase catalyzing C4 demethylation in the Kandutsch-Russell branch of the cholesterol biosynthesis pathway. FAXDC2, a paralog of MSMO1, regulates th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c662cd9-762f-560e-92df-4e8fa9530798
DOI: 10.1101/2023.12.15.571793

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signalingDOI 10.1101/2023.12.15.571793Read

Lipid metabolism gene ECI2 affects neutrophil extracellular traps by inhibiting ether lipid production to suppress colorectal cancer invasion and metastasisSemantic proximity Read

Canonical WNT signaling-driven DKC1 dysregulates sphingolipid biosynthesis and drives colorectal cancer.Semantic proximity Read

ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cellsSemantic proximity Read

Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signalingSemantic proximity Read

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolismSemantic proximity Read

SQLE-mediated squalene metabolism is critical for mitochondrial biogenesis and tumor development in K-ras-driven cancerSemantic proximity Read

Crosstalk between Fat Mass and Obesity-related (FTO) and multiple WNT signaling pathwaysSemantic proximity Read

MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLESemantic proximity Read

TGFβ-dependent upregulation of OCIAD2 is essential for epithelial-to-mesenchymal transition during mesendoderm differentiationSemantic proximity Read

The lysine demethylase dKDM2 is non-essential for viability, but regulates circadian rhythms in <i>Drosophila</i>Semantic proximity Read

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptorSemantic proximity Read

The Lipid Elongation Enzyme ELOVL2 is a molecular regulator of aging in the retinaSemantic proximity Read