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Article

Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway.

The Journal of biological chemistry - 8 Aug 2003

Xiao Jia-Hao, Ghosn Corine, Hinchman Cory, Forbes Chad, Wang Jenny, Snider Nonna, Cordrey Allison, Zhao Yi, Chandraratna Roshantha A S

Abstract excerpt

Beta-catenin is a component of stable cell adherent complexes whereas its free form functions as a transcription factor that regulate genes involved in oncogenesis and metastasis. Free beta-catenin is eliminated by two adenomatous polyposis coli (APC)-dependent proteasomal degradation pathways regulated by glycogen synthase kinase 3beta (GSK3 beta) or p53-inducible Siah-1. Dysregulation of beta-catenin turnover...

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PMID: 12771132
DOI: 10.1074/jbc.M304761200

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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