Article
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.
Nature communications - 1 Jan 2013
Voloshanenko Oksana, Erdmann Gerrit, Dubash Taronish D, Augustin Iris, Metzig Marie, Moffa Giusi, Hundsrucker Christian, Kerr Grainne, Sandmann Thomas, Anchang Benedikt, Demir Kubilay, Boehm Christina, Leible Svenja, Ball Claudia R, Glimm Hanno, Spang Rainer, Boutros Michael
Abstract excerpt
Aberrant regulation of the Wnt/β-catenin pathway has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or β-catenin. However, it has remained a point of controversy whether these mutations are sufficient to activate the pathway or require additional upstream signals. Here we show that colorectal tumours express...
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