Article

RNA G-quadruplexes mediate cooperativity in HNRNPH binding and splicing regulation

2026-03-03

Abstract excerpt

Alternative splicing, regulated by RNA-binding proteins (RBPs), enables the generation of diverse transcript isoforms critical for cellular function. However, how RNA secondary structure impacts RBP binding and function remains poorly understood. Here, we unravel how RNA G-quadruplexes (rG4s) facilitate cooperativity in splicing regulation by the RBP heterogeneous nuclear ribonucleoprotein H (HNRNPH). Through high...

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Literature Corpus work: 04291b81-1a40-5f1d-8fdb-af2a2be37bd3
DOI: 10.64898/2026.03.03.709289

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