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Article

Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis.

Nature communications - 17 Aug 2018

Braun Simon, Enculescu Mihaela, Setty Samarth T, Cortés-López Mariela, de Almeida Bernardo P, Sutandy F X Reymond, Schulz Laura, Busch Anke, Seiler Markus, Ebersberger Stefanie, Barbosa-Morais Nuno L, Legewie Stefan, König Julian, Zarnack Kathi

Abstract excerpt

Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to decode the cis-regulatory landscape that determines alternative splicing of exon 11 in the proto-oncogene MST1R (RON). Mathematical modelling of splicing kinetics enables us to identify more than 1000 mutations affecting RON exon 11...

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Identifiers

PMID: 30120239
DOI: 10.1038/s41467-018-05748-7
PMCID: PMC6098099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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