Article

CRIC-seq reveals positional rule of PTBP1-mediated long-range RNA looping in splicing regulation

2022-08-11

Abstract excerpt

<h4>SUMMARY</h4> RNA-binding proteins bind at different positions of pre-mRNA molecules to promote or reduce the usage of a particular exon. Seeking to understand the working principle of these positional effects, we develop a CRIC-seq method to enrich single RBP-mediated in situ RNA-RNA spatial interacting fragments for deep sequencing. We determine hnRNPA1- and PTBP1-mediated RNA-RNA interactions and regulatory...

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Literature Corpus work: 7e8927f2-9c4b-54fb-8353-6ae14672d8f0
DOI: 10.1101/2022.08.09.503273

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