Article

TDP-43 regulates chromatin looping and gene transcription through binding and stabilizing DNA G-quadruplex structures

2026-05-15

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is a multifunctional DNA/RNA-binding protein implicated in transcriptional and post-transcriptional regulation. Dysregulation of TDP-43 is closely correlated with human diseases such as cancer and neurodegenerative diseases. Although its roles in RNA metabolism are well characterized, its function in transcriptional regulation remains largely underexplored. DNA G-quadruplexes (d...

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Literature Corpus work: 1fb57079-7af8-574f-8a71-a1342f930d81
DOI: 10.64898/2026.05.13.724493

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